Experimental investigation of perturbation Monte-Carlo based derivative estimation for imaging low-scattering tissue.

Experimental results for imaging the low-scattering tissue phantoms based on the derivative estimation through perturbation Monte-Carlo (pMC) method are presented. It is proven that pMC-based methods give superior reconstructions compared to diffusion-based reconstruction methods. An easy way to estimate the Jacobian using analytical expression obtained from perturbation Monte-Carlo method is employed. Simulation studies on the same objects, considered in the experiment, are performed and corresponding results are found to be in reasonable agreement with the experimental studies. It is shown that inter-parameter cross talk in diffusion based methods lead to false results for the low-scattering tissue, where as the pMC-based method gives accurate results.